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Regulation of pancreatic beta-cell growth and survival by the serine/threonine kinase Akt1/PKB(alpha)

Article Abstract:

Research has been conducted on the serine/threonine kinase Akt1/PKB(alpha). The metabolic role of AKT in a mammalian model has been investigated via the creation of a transgenic mouse with the active form of Akt1 expressed in the pancreatic beta cells.

Author: Furth, Emma E., Birnbaum, Morris J., Polonsky, Kenneth S., Tuttle, Robyn L., Gill, Navdeep S., Pugh, William, Lee, Jean-Pyo, Koeberlein, Brigitte, Naji, Ali
Publisher: Nature America, Inc.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2001
Statistical Data Included, Analysis, Physiological aspects, Genetic aspects, Medical research, Cells (Biology), Growth, Metabolism, Cells, Serine, Threonine, Pancreatic beta cells

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Stem cells act through multiple mechanisms to benefit mice with neurodegenerative metabolic disease

Article Abstract:

This article discusses how mice affected with neurodegenerative metabolic disease are used to show how intra-cranial transplantation of neural stem cells delayed the disease. A detailed explanation is provided which shows that stem cells possess properties that prolong the survival of the disease-infected mouse.

Author: Snyder, Evan Y., Butters, Terry D., Dwek, Raymond A., Platt, Frances M., Lipton, Stuart A., Lee, Jean-Pyo, Clarke, Jonathan, Gang Tong, Jeyakumar, Mylvaganam, Wenger, David, Gonzalez, Rodolfo, Takahashi, Hiroto, Lee, Pei-Jen, Seyfried, Thomas N., Baek, Rena C., Clark, Dan, Rose, Heather, Schwartz, Philip, Fu, Gerald, McKercher, Scott, Meerloo, Jennifer, Muller, Franz-Josef, Kook In Park
Publisher: Nature America, Inc.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2007
Causes of, Risk factors, Nervous system, Stem cells, Neurodegenerative diseases

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B lymphocyte-directed immunotherapy promotes long-term islet allograft survival in nonhuman primates

Article Abstract:

The importance of the B lymphocyte-directed immunotherapy in promoting long-term islet allograft survival in nonhuman primates is discussed. It is observed that B lymphocytes highly increase the chances of the primates' achievement of humoral transplantation tolerance.

Author: Koeberlein, Brigitte, Naji, Ali, Tomaszewski, John E., Barker, Clyde F., Chengyang Liu, Noorchashm, Hooman, Green, Taryn, Sutter, Jennifer A., Naji, Mina, Prak, Eline Luning, Rickels, Michael R., Zhonglin Wang, Paessler, Michelle E., Velidedeoglu, Ergun, Rostami, Susan Y., Ming Yu, Boyer, Jean
Publisher: Nature America, Inc.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2007
Care and treatment, Type 1 diabetes, B cells, Primates, Immunotherapy, Rituximab

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Subjects list: United States, Health aspects, Research
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