Amniotic fluid inflammatory cytokines (interleukin-6, interleukin-1beta, and tumor necrosis factor-alpha), neonatal brain white matter lesions, and cerebral palsy

Article Abstract:

Certain elevated cytokine levels in amniotic fluid appear to increase the risk for the infant to have some type of brain damage and possibly cerebral palsy. Amniotic fluid samples were examined for the cytokines interleukin-1B, interleukin-6, interleukin-1 receptor antagonist, and tumor necrosis factor-a in 94 women with complicated pregnancies. Brain scans were performed on the newborns. Women with higher interleukin-1B and interleukin-6 amniotic levels were at 4.4 and 5.7 times greater risk, respectively, of having an infant with some brain damage. Cytokine levels were high for all eight infants with cerebral palsy.

Analysis, Measurement, Cerebral palsy, Interleukins, Cytokines, Amniotic fluid

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An elevated amniotic fluid matrix metalloproteinase-8 level at the time of mid-trimester genetic amniocentesis is a risk factor for spontaneous preterm delivery

Article Abstract:

Increased amounts of an enzyme called matrix metalloproteinase-8 in the amniotic fluid of pregnant women is a strong risk factor for premature birth. This measurement could be done whenever a pregnant woman has an amniocentesis for genetic reasons.

Health aspects, Premature birth, Metalloenzymes

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