Analytical and biologic variability in measures of hemostasis, fibrinolysis, and inflammation: assessment and implications for epidemiology

Article Abstract:

Epidemiologic research may rely on some alternative risk markers of cardiovascular diseases without having established the inherent variability factor. Twenty-six healthy people underwent a series of hemostatic testing for six months, including fibrinolysis and inflammation assays. The assay variation within participants was significant, suggesting a type of biovariability similar to that of cholesterol. Essay selection may aid the design of epidemiological research models.

Measurement, Hemostasis, Fibrinolysis

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Prospective study of intentionality of weight loss and mortality in older women: The Iowa Women's Health Study

Article Abstract:

Patterns of weight loss and subsequent mortality in post-menopausal women may be more complex than previously thought. Among a total of 25,897 older women, those who had unintentionally lost more than 20 pounds had a higher risk of dying than women without such weight changes. Unintentional weight loss was linked to cardiovascular mortality and overall mortality. The pattern of mortality relative to body weight fluctuations may be related to underlying health conditions.

Patient outcomes, Weight loss, Postmenopausal women

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Consequences of the use of different measures of effect to determine the impact of age on the association between obesity and mortality

Article Abstract:

A study that used mortality data to determine whether the relationship between weight and mortality varies time is discussed. Results indicate that years of life lost as a result of obesity increased with age but the rate of increase attributable to obesity dropped after age 70.

Statistical Data Included, Analysis, Statistics, Epidemiological research, Cross sectional studies, Medical statistics

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