Antiretroviral-associated toxicity among HIV-1-seropositive pregnant women in Mozambique receiving nevirapine-based regimens

Article Abstract:

A prospective cohort study is used to assess toxicities associated with highly active antiretroviral therapy (HAART) among HIV-1-infected Mozambican pregnant women treated with nevirapine-based regimens. The results have shown that severe hepatoxicity from nevirapine-containing HAART in this cohort of pregnant women was more common at higher CD4 counts, proposing that laboratory monitoring is necessary when administering nevirapine-containing regimens to pregnant women with CD4 counts greater than or equal to 250 cells/[micro]L.

Mozambique, Risk factors, Pregnant women, Highly active antiretroviral therapy

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Enzyme inducers reduce elimination half-life after a single dose of nevirapine in healthy women

Article Abstract:

A pilot study's primary objective was investigating the effect of intervention strategies with a number of agents on the elimination half-life of nevirapine (NVP). Appropriately powered safety and feasibility end point studies are required to be conducted before these interventions can be tested in the setting of single-dose NVP (SD-NVP) for the prevention of mother-to-child transmission (MTCT) (PMTCT) of HIV for reducing the development of NVP resistance.

Prevention, Disease transmission

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Early response to highly active antiretroviral therapy in HIV-1-infected Kenyan children

Article Abstract:

The early response to World Health Organization (WHO) that had recommended nonnucleoside reverse transcriptase inhibitor (NNRT1) containing highly active antiretroviral therapy (HAART) in HIV-1-infected Kenyan children unexposed to nevirapine is described. It is observed that there is good early clinical and virologic response to NNRTI-based HAART.

Kenya, HIV infection, HIV infections

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