Nelfinavir, efavirenz, or both after the failure of nucleoside treatment of HIV infection

Article Abstract:

Treating HIV patients with the protease inhibitor nelfinavir and the non-nucleoside reverse transcriptase inhibitor efavirenz is more effective than using either drug alone, especially when combined with a third drug. This was the conclusion of a study of 195 HIV patients.

Evaluation, Drug therapy, Combination, Combination drug therapy

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Antiretroviral therapy for HIV infection in 1996: recommendations of an international panel

Article Abstract:

The International AIDS Society-USA has published updated guidelines on drug therapy for HIV infection. All HIV-infected patients whose CD4 cell counts have dropped below 500 should be treated. Initially, combinations of nucleoside analogs such as zidovudine, didanosine and zalcitabine should be used. Patients with more advanced disease could receive a nucleoside analog plus a protease inhibitor such as saquinavir, indinavir or ritonavir. Patients should be switched to another drug or drug combination if they experience severe side effects or become resistant to the initial drug.

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Anti retroviral Therapy for HIV Infection in 1998, Part 2

Article Abstract:

The International AIDS Society-USA recommends early antiviral therapy, guided by viral load monitoring, for people infected with HIV. Patients effectively treated with a combination of protease inhibitor and reverse transcriptase inhibitor antiretroviral medications for over 2 years do not develop drug-resistant viral mutations. Early drug treatment substantially reduces hospitalizations and illness among HIV patients. Viral load monitoring can indicate the effectiveness of drug treatment regimens and guide changes in therapy.

Health aspects, Reports, Measurement, Antiviral agents, Viremia, Viral load, International AIDS Society

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