Antiretrovirals induce direct endothelial dysfunction in vivo

Article Abstract:

The male Sprague-Dawley rats were treated with clinically relevant doses of azidothymidine (AZT) and/or indinavir similar to those administered in humans to determine whether nucleoside reverse transcriptase inhibitors (NRTI) and/or protease inhibitors induce endothelial dysfunction. The findings suggest that in addition to the lipid disorders induced by protease inhibitors and mitochondrial DNA depletion in myocardial cells, direct endothelial dysfunction induced by AZT and perhaps other NRTIs might contribute to the development of cardiovascular complications observed in HIV patients.

Drug overview

---

HIV-1 reverse transcriptase mutants resistant to nonnucleoside reverse transcriptase inhibitors do not adversely affect DNA synthesis: Pre-steady-state and steady-state kinetic studies

Article Abstract:

The polymerase function of 3 clinically occurring nonnucleoside reverse transcriptase inhibitor (NNRTI)-resistant RTs in greater detail, under both pre-steady-state and steady-state conditions is evaluated. Results indicate that the close proximity of the NNRTI-resistance mutations to the polymerase active site does not affect the interactions of the enzyme with the incoming nucleotide or the primer-template sufficiently to affect polymerization.

DNA synthesis, Reverse transcriptase inhibitors

---

Therapeutic drug monitoring of Efavirenz: Trough levels cannot be estimated on the basis of earlier plasma determinations

Article Abstract:

An experiment was conducted to find out whether a limited sampling strategy could provide a good estimation of efavirenz (EFV) trough levels and area under the curve (AUC). The weak association observed between EFV plasma levels and treatment outcomes in the study might explain that no adequate substitute for collecting blood 24 hours after dosing emerged from the analysis.

Methods, Complications and side effects, Drug utilization, Drug monitoring, Efavirenz (Medication)

Similar abstracts:

• Abstracts: Dofetilide in patients with congestive heart failure and left ventricular dysfunction. N-terminal pro-B-type natriuretic peptide and long-term mortality in stable coronary heart disease
• Abstracts: Redefining lipodystrophy syndrome: Risks and impact on clinical decision making. Lipodystrophy and dyslipidemia among patients taking first-line, World Health Organization-recommended highly active antiretroviral therapy regimens in western India
• Abstracts: Highly active antiretroviral therapy attenuates re-endothelialization and alters neointima formation in the rat carotid artery after balloon injury
• Abstracts: Immune-based therapies: Clinical experience with immunomodulators and therapeutic immunization
• Abstracts: Can we learn a few things from Google? Telemetry monitoring: A preferred solution for intermediate care. New graduate programs ease nurse shortages while educating

This website is not affiliated with document authors or copyright owners. This page is provided for informational purposes only. Unintentional errors are possible.