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Complete genomic screen in parkinson disease: evidence for multiple genes

Article Abstract:

Researchers have identified five genes that may contribute to the development of Parkinson's disease by screening 870 people in 174 families. The genes are on chromosomes 6q, 17q, 8p, 5q, and 9q.

Author: Jankovic, Joseph, Roses, Allen D., Pericak-Vance, Margaret A., Small, Gary W., Haines, Jonathan L., Scott, William K., Nance, Martha A., Watts, Ray L., Hubble, Jean P., Koller, William C., Lyons, Kelly, Pahwa, Rajesh, Stern, Matthew B., Colcher, Amy, Hiner, Bradley C., Ondo, William G., Allen Jr., Fred H., Goetz, Christopher G., Masterman, Donna, Mastaglia, Frank, Laing, Nigel G., Stajich, Jeffrey M., Slotterbeck, Brandon, Booze, Michael W., Ribble, Robert C., Rampersaud, Evadnie, West, Sandra G., Gibson, Rachel A., Middleton, Lefkos T., Scott, Burton L., Vance, Jeffery M.
Publisher: American Medical Association
Publication Name: JAMA, The Journal of the American Medical Association
Subject: Health
ISSN: 0098-7484
Year: 2001

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Association of single-nucleotide polymorphisms of the tau gene with late-onset parkinson disease

Article Abstract:

A genetic polymorphism in the human tau gene on chromosome 17q21 appears to be associated with an increased susceptibility to Parkinson's disease, according to a study of 1,056 individuals from 235 families. Genetic polymorphisms are minor variations in normal genes that can predispose people to certain diseases.

Author: Jankovic, Joseph, Roses, Allen D., Pericak-Vance, Margaret A., Small, Gary W., Haines, Jonathan L., Scott, William K., Nance, Martha A., Watts, Ray L., Hubble, Jean P., Koller, William C., Lyons, Kelly, Pahwa, Rajesh, Stern, Matthew B., Colcher, Amy, Hiner, Bradley C., Ondo, William G., Allen Jr., Fred H., Goetz, Christopher G., Masterman, Donna, Mastaglia, Frank, Laing, Nigel G., Stajich, Jeffrey M., Booze, Michael W., Ribble, Robert C., Gibson, Rachel A., Middleton, Lefkos T., Scott, Burton L., Vance, Jeffery M., Martin, Eden R., Rogala, Allison, Hauser, Michael A., Zhang, Fengyu
Publisher: American Medical Association
Publication Name: JAMA, The Journal of the American Medical Association
Subject: Health
ISSN: 0098-7484
Year: 2001
Health aspects, Genetic polymorphisms

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Apolipoprotein E type 4 allele and cerebral glucose metabolism in relatives at risk for familial Alzheimer disease

Article Abstract:

People with a family history of Alzheimer's disease (AD) who inherit the apolipoprotein (apo) E 4 allele may have a slower rate of brain glucose metabolism than other people. The apo E 4 allele is a form of the apo E gene that is associated with an increased risk of late-developing AD. Researchers used positron emission tomography to measure brain glucose metabolism in seven people with probable AD and in 31 nondemented people who had a family history of AD. Twelve of the nondemented people had the apo E 4 allele. Nondemented people with the apo E 4 allele had a significantly lower rate of glucose metabolism in the left and right sides of the brain than the other nondemented people. In addition, the difference in the glucose metabolic rate in the right and left sides of the brain was significantly greater in nondemented people with the apo E 4 allele. People with probable AD had lower rates of glucose metabolism in both sides of the brain than nondemented people with the apo E 4 allele.

Author: Roses, Allen D., Saunders, Ann M., Pericak-Vance, Margaret A., Mazziotta, John C., Small, Gary W., Phelps, Michael E., Haines, Jonathan L., Guze, Barry H., Collins, Mark T., Baxter, Lewis R., Mandelkern, Mark A., Kaplan, Andrea, La Rue, Asenath, Adamson, Cara F., Chang, Linda, Corder, Elizabeth H.
Publisher: American Medical Association
Publication Name: JAMA, The Journal of the American Medical Association
Subject: Health
ISSN: 0098-7484
Year: 1995
Measurement, Physiological aspects, Alzheimer's disease, Brain, Apolipoproteins, Glucose metabolism, Radionuclide imaging

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Subjects list: Genetic aspects, Parkinson's disease, Parkinson disease
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