Abstracts - faqs.org

Abstracts

Health

Search abstracts:
Abstracts » Health

Resistance to diet-induced hypercholesterolemia and gallstone formation in ACAT2-deficient mice

Article Abstract:

Research on laboratory mice indicates that acyl CoA:cholesterol acyltransferase (ACAT2) deficiency provides a significant level of resistance to cholesterol-induced gallstones and hypercholesterolemia. Inhibition of ACAT2 may therefore be a successful strategy for treating or preventing diseases related to cholesterol-rich diets.

Author: Buhman, Kimberly K., Accad, Michel, Novak, Sabine, Choi, Rebekah S., Wong, Jinny S., Hamilton, Robert L., Turley, Stephen, Farese, Robert V., Jr.
Publisher: Nature America, Inc.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2000
Health aspects, Causes of, Gallstones, Diet, Hypercholesterolemia, Diet in disease, Esters, Cholesterol metabolism

User Contributions:

Comment about this article or add new information about this topic:

CAPTCHA

Turning WAT intp BAT gets rid of fat

Article Abstract:

Research has been conducted on the knockout mouse models of leanness and obesity resistance. The generation of the new lean mouse model via inactivating the gene for an inhibitor of mRNA translation has been carried out and discussed.

Author: Farese, Robert V., Jr., Chen, Hubert C.
Publisher: Nature America, Inc.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2001
Obesity, Leanness, Genetics, Fat, Fats, Brown adipose tissue

User Contributions:

Comment about this article or add new information about this topic:

CAPTCHA

Adipose tissue reduction in mice lacking the translational inhibitor 4E-BP1

Article Abstract:

Research has been conducted on the nuclear-encoded mRNA containing a 5' cap structure recognized by the eukaryotic translation initiation factor 4E (elF4E) subunit of the elF4E complex. The biological function of elF4E has been investigated via the disruption of its gene in the mouse.

Author: Spiegelman, Bruce M., Sonenberg, Nahum, Gingras, Anne-Claude, Tsukiyama-Kohara, Kyoko, Poulin, Francis, Kohara, Michinori, DeMaria, Christine T., Cheng, Alan, Wu, Zhidan, Katsume, Asao, Elchebly, Mounib, Harper, Mary-Ellen, Tremblay, Michel L.
Publisher: Nature America, Inc.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2001
Canada, Japan

User Contributions:

Comment about this article or add new information about this topic:

CAPTCHA


Subjects list: Statistical Data Included, United States, Physiological aspects, Analysis, Genetic aspects, Medical research, Messenger RNA, Adipose tissues, Adipose tissue
Similar abstracts:
  • Abstracts: PPAR-alpha and PPAR-gamma activators induce cholesterol removal from human macrophage foam cells through stimulation of the ABCA1 pathway
  • Abstracts: Ethical issues concerning research in complementary and alternative medicine. The ethics of placebo-controlled trials -- a middle ground
  • Abstracts: Comparison of the Canadian CT Head Rule and the New Orleans Criteria in patients with minor head injury. The Canadian C-Spine Rule for Radiography in Alert and Stable Trauma Patients
  • Abstracts: Parkin ubiquitinates the alpha-synuclein-interacting protein, synphilin-1: implications of Lewy-body formation in Parkinson disease
  • Abstracts: Modulation of anxiety through blockade of anandamide hydrolysis. Cannabinoid activity curtails cocain craving
This website is not affiliated with document authors or copyright owners. This page is provided for informational purposes only. Unintentional errors are possible.
Some parts © 2025 Advameg, Inc.