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Mouse gene targeting: fourty years with homologous recombination

Article Abstract:

The author discusses his contribution to the homologous recombination use in modifying genes in the mouse genome. The invention by the author of the high resolution gel electrophoresis is described.

Author: Smithies, Oliver
Publisher: Nature America, Inc.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2001
Research, Usage, Gel electrophoresis, Genomes, Homology (Biology)

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Epilepsy and all that jazz

Article Abstract:

Research has been conducted on the reflex epilepsies caused by different sensory stimuli. The mechanism of the neuronal excitability has been investigated via the study of the mutated gene that causes epileptic seizures in response to loud noises and the results are reported.

Author: Puranam, Ram S., McNamara, James O.
Publisher: Nature America, Inc.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2001
Epilepsy

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Parkin ubiquitinates the alpha-synuclein-interacting protein, synphilin-1: implications of Lewy-body formation in Parkinson disease

Article Abstract:

Research has been conducted on the Parkinson disease characterized by the dopaminergic neurons loss and the presence of intracytoplasmic-ubiquitinated inclusions, Lewy bodies. The absence of the Lewy body in the patients with the parkin mutations has been investigated and the results suggest that parkin may be required for the Lewy body formation.

Author: Dawson, Ted M., Zhang, Yi, Chung, Kenny K. K., Lim, Kah Leong, Tanaka, Yuji, Huang, Hui, Gao, Jun, Ross, Christopher A., Dawson, Valina L.
Publisher: Nature America, Inc.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2001
Statistical Data Included, Proteins, Parkinson's disease, Parkinson disease

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Subjects list: United States, Analysis, Physiological aspects, Gene mutations, Gene mutation, Medical research, Causes of, Neurons
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