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Blockade of the MAP kinase pathway suppresses growth of colon tumors in vivo

Article Abstract:

Blockade of the mitogen-activated protein (MAP) kinase pathway has been found to suppress growth of colon tumors. A highly potent and selective inhibitor of the orally active upstream kinase MEK has been found. Tumor growth was inhibited as much as 80% in mice with colon carcinomas of both mouse and human origin after treatment with the inhibitor.

Author: Saltiel, Alan R., Sebolt-Leopold, Judith S., Dudley, David T., Herrera, Roman, Van Becelaere, Keri, Wiland, Amy, Gowan, Richard C., Tecle, Haile, Barrett, Stephen D., Bridges, Alexander, Przybranowski, Sally, Leopold, W.R.
Publisher: Nature America, Inc.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 1999
Usage, Colorectal cancer, Protein kinases, Physiology

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Mice deficient in tumor necrosis factor-alpha are resistant to skin carcinogenesis

Article Abstract:

Mice lacking in tumor necrosis factor-alpha (TNF-alpha), which is a pro-inflammatory cytokine, have been found to be resistant to skin carcinogenesis. Neutralizing TNF-alpha production is potentially useful in cancer treatment/prevention, but has little influence on later carcinogenesis stages.

Author: Kollias, George, Moore, Robert J., Balkwill, Frances, Pasparakis, Manolis, Rollins, Barrett, Owens, David M., Stamp, Gordon, Arnott, Caroline, Burke, Frances, East, Nick, Holdsworth, Hazel, Turner, Lynn
Publisher: Nature America, Inc.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 1999
United Kingdom, Greece, Prevention, Cancer, Cancer prevention, Tumor necrosis factor, Carcinogenesis, Skin cancer

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Dengue virus and dendritic cells

Article Abstract:

Research presented concerns the function of dentritic or antigen-presenting cells, focusing on their role in the pathogenesis of the Dengue virus. Topics addressed include the regulation of immune responses to Dengue virus infection.

Author: Palucka, Anna Karolina
Publisher: Nature America, Inc.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2000
Infection, Antigen presenting cells, Dengue viruses, Dengue virus

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Subjects list: Statistical Data Included, Research, United States, Physiological aspects, Mice, Mice (Rodents), Immunocytochemistry
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