CD40 antibody evokes a cytotoxic T-cell response that eradicates lymphoma and bypasses T-cell help

Article Abstract:

CD40 antibody has been found to evoke a cytotoxic T-cell response that eradicates lymphoma and bypasses T-cell help. In a study it has been seen that when antibody against CD40 is used to treat mice with syngeneic lymphoma, a rapid cytotoxic T-cell response independent of T-helper cells takes place, with expansion by a factor of 10 in CD8(super.+) T cells over 5 days.

United Kingdom, Physiological aspects, Mice, Mice (Rodents), Cytochemistry, Lymphomas

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T-cell stimulation: an abundance of B7s

Article Abstract:

Four B7 proteins have been discovered and there may be others. These proteins bind to T cells and provide the co-stimulatory signal that activates them to recognize a particular antigen. Research on this topic could uncover treatments for graft rejection and autoimmune disease.

Immune response

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