Induction of cytotoxic T cell responses and tumor immunity against unrelated tumors using telomerase reverse transcriptase RNA transfected dendritic cells

Article Abstract:

Research demonstrates that mice immunized with dendritic cells transfected with murine polypeptide component of telomerase-RNA elicits telomerase-specific cytotoxic T lymphocyte response, which recognize, inhibit, and lyse tumor targets from diverse genetic backgrounds. Data further indicate that dendritic cells transfected with tumor dendritic cells stimulate a tumor-specific immune response.

United States, Genetic aspects, Cell-mediated cytotoxicity, Cell mediated cytotoxicity, Immune response, Telomerase, Tumor antigens, Immune response regulation

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Scrapie replication in lymphoid tissues depends on prion protein-expressing follicular dendritic cells

Article Abstract:

Follicular dendritic cells that express the normal prion protein appear to be involved in the replication of the abnormal form of the protein in the spleen. This was the conclusion of researchers who used a mouse model of scrapie.

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Prion replication -- once again blaming the dendritic cell

Article Abstract:

Follicular dendritic cells in the spleen appear to be responsible for replication of the scrapie protein. These cells produce the normal prion protein, and replication only occurs in cells that express the normal prion protein.

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