Chorioamnionitis and increased neonatal lung lavage fluid matrix metalloproteinase-9 levels: implications for antenatal origins of chronic lung disease

Article Abstract:

A uterine infection called chorioamnionitis may stimulate the production of matrix metalloproteinase-9, an enzyme that degrades collagen. In a study of 79 premature babies who were on a mechanical ventilator, those who were exposed to chorioamnionitis before birth had higher amounts of this enzyme in fluid taken from their lungs. This could explain why premature babies often have lung disease, especially when the premature birth is caused by chorioamnionitis.

Causes of, Infants (Premature), Premature infants, Metalloenzymes

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High prevalence of viral genomes and inflammation in peripartum cardiomyopathy

Article Abstract:

The high prevalence of virus-associated inflammatory changes in peripartum cardiomyopathy is discussed. Viral genomes associated with interstitial inflammation are found in 8 patients after molecular pathologic examination of endomyocardial biopsy specimens from 26 patients with peripartum cardiomyopathy.

United States, Science & research, Research, Diagnosis, Heart diseases, Cardiomyopathy, Myocardial diseases, Viral genetics

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Chorioamnionitis and inflammation of the fetal lung

Article Abstract:

An infection of the fetal membranes called chorioamnionitis may create an inflammatory response in the baby's lungs. This was the conclusion of a study of 27 fetal cadavers, which found increased levels of inflammatory substances in the lungs of seven fetuses who had been exposed to chorioamnionitis.

Fetus, Lungs, Inflammation

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