Chorion-induced myometrial relaxation is mediated by large-conductance Ca(super 2+)-activated K+ channel opening in the guinea pig

Article Abstract:

The fetal membranes that make up the placenta produce a substance that keeps the uterus from contracting by opening calcium-activated potassium channels, according to a study in the guinea pig. This substance can keep the uterus from contracting even in the presence of oxytocin, which normally causes the uterus to contract. The uterus of a pregnant animal must remain quiet until the baby is ready to be born.

Prevention, Potassium channels, Placenta, Uterine contractions

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Identification of interactive gene networks: A novel approach in gene array profiling of myometrial events during guinea pig pregnancy

Article Abstract:

The transition from myometrial quiescence to activation is poorly understood so functional analysis and logical operations were applied along regulatory gene networks to identify molecular processes and pathways underlying quiescence and activation. The result reveals a global and comprehensive analysis of the pregnancy-associated changes in the myometrial gene expression.

United States, Science & research, Research, Genetic aspects, Pregnancy, Myometrium, Clinical report

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Effects of acute and chronic hypoxia on nitric oxide-mediated relaxation of fetal guinea pig arteries

Article Abstract:

Low levels of oxygen appear to inhibit arterial relaxation caused by nitric oxide. This was the conclusion of a study of guinea pigs. The study also showed that the arteries change to accommodate the lower oxygen levels.

Hypoxia, Anoxia, Nitric oxide, Blood vessels, Vasodilation

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