Virus-specific cytotoxic T-lymphocyte responses select for amino-acid variation in simian immunodeficiency virus Env and Nef

Article Abstract:

HIV may outmaneuver the immune system by accumulating amino acid replacements in the Env and Nef proteins that allow the virus to evade cell-mediated cytotoxicity. This was demonstrated in macaques infected with SIV, which during the monkeys' lifetime altered 10 different epitopes that eliminated MHC class I recognition and binding.

Prevention, Physiological aspects, HIV (Viruses), HIV, Cell-mediated cytotoxicity, Cell mediated cytotoxicity

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Safer, longer-lasting regulatory T cells with [beta]-catenin

Article Abstract:

The impact of the stabilized form of [beta]-catenin on the extension of the lifespan of regulatory T cells is discussed. These enhanced T cells are found to be of a lot of help in the cell therapy strategies used for the treatment of several diseases and disorders.

Science & research, Research, T cells, Homeostasis, Cellular therapy, Cell therapy, Apoptosis

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