Cytokine-induced secretion of monocyte chemotactic protein-1 by human endometriotic cells in culture

Article Abstract:

Under the influence of interleukin-1beta (IL-1beta) and tumor necrosis factor-alpha (TNF-alpha), endometriotic tissue is capable of producing a chemical attractant for macrophages, a white blood cell involved in the inflammatory process. IL-1beta and TNF-alpha are inflammation stimulating substances found in the peritoneal fluid of women with endometriosis. Recruitment of macrophages is also a hallmark of endometriosis. Endometriotic tissue was obtained from six women undergoing laparoscopy. Tissues were dissociated into component cells, cultured, and incubated with different concentrations of inflammatory stimulants. The culture fluid was assayed for the presence of monocyte chemotactic protein-1 (MCP-1). IL-1beta and TNF-alpha stimulated release of MCP-1 in a time- and dose-dependent manner. TNF-1 and interferon-gamma (IFN-gamma) had a synergistic effect on MCP-1 production, whereas IFN-gamma alone had no effect.

Research, Chemotaxis, Cytokines

---

Expression of dioxin-related transactivating factors and target genes in human eutopic endometrial and endometriotic tissues

Article Abstract:

Researchers have detected a possible link between dioxin exposure and endometriosis. They detected increased expression of genes that are stimulated by dioxin in endometrial samples from women with endometriosis as well as increased levels of a receptor that binds dioxin.

Causes of, Dioxin, Dioxins

---

Endometriotic umbilical port site metastasis after laparoscopy

Article Abstract:

A case was presented pertaining to a 40-year-old woman who had previously been operated for endometrioma fews years ago by laparoscopy. Complains regarding an umbilical mass with cyclical pain pattern revealed it to be an endometriotic implant.

United States, Care and treatment, Case studies, Complications and side effects, Fetal diseases, Laparoscopy

Similar abstracts:

• Abstracts: Effects of tibolone on nuclear receptors in human endometrial cells. Glycodelin reduces carcinoma-associated gene expression in endometrial adenocarcinoma cells
• Abstracts: Hysteroscopic injection of tracers in sentinel node detection of endometrial cancer: a feasibility study. Endometrial cancer in women 45 years of age or younger: A clinicopathological analysis
• Abstracts: Aberrant induction of regulatory activity of [CD4.sup.+][CD25.sup.+] T cells by dendritic cells in HIV-infected persons with amebic liver abscess
• Abstracts: The secret ingredient. A risk assessment scale for pressure ulcers in children
• Abstracts: Role of the sodium-calcium exchange mechanism and the effect of magnesium on sodium-free and high potassium contractures in pregnant human myometrium

This website is not affiliated with document authors or copyright owners. This page is provided for informational purposes only. Unintentional errors are possible.