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Cytokine therapy for Crohn's disease: Advances in translational research

Article Abstract:

Crohn's disease (CD) is an inflammatory bowel disease, and cytokines are vital in the pathogenesis of CD. New concepts in CD pathogenesis and roles of cytokines in the initiation and perpetuation of disease, and the application of cytokine-based therapies in human clinical trials and preclinical animal studies, are discussed.

Author: Pizarro, Theresa T., Cominelli, Fabio
Publisher: Annual Reviews, Inc.
Publication Name: Annual Review of Medicine
Subject: Health
ISSN: 0066-4219
Year: 2007
United States, Complications and side effects, Drug therapy, Dosage and administration, Cytokines, Crohn's disease, Clinical report

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Herpes simplex: insights on pathogenesis and possible vaccines

Article Abstract:

Several human genetic studies are conducted to explain the severity, pathogenesis, as well as the vaccines available for the prevention of herpes simplex virus (HSV). The findings show that the HSV-2 transmission can be easily decreased by the suppression of the viral shedding by using the nucleoside analog drugs.

Author: Corey, Lawrence, Koelle, David M.
Publisher: Annual Reviews, Inc.
Publication Name: Annual Review of Medicine
Subject: Health
ISSN: 0066-4219
Year: 2008
Health aspects, HIV infection, HIV infections, Herpes simplex virus, Lymphocytes

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The impact of the completed human genome sequence on the development of novel therapeutics for human disease

Article Abstract:

The medical benefits of the human genome sequence are discussed. The study on human genome is applied to determine the disease causation at the molecular level, improved diagnosis and disease classification based on genetic profiles.

Author: Austin, Christopher P.
Publisher: Annual Reviews, Inc.
Publication Name: Annual Review of Medicine
Subject: Health
ISSN: 0066-4219
Year: 2004
Therapeutics, Therapeutics, Experimental

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Subjects list: Research, Genetic aspects, Genetic translation, Translation (Genetics), Human genome
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