DNase Sda1 provides selection pressure for a switch to invasive group A streptococcal infection

Article Abstract:

Researchers have described how bacteriophage-encoded group A Streptococcus (GAS) DNase (Sda1), which has facilitated the pathogen's escape from neutrophil extracellular traps, has served as a selective force for controlling the virulence regulatory sensor kinase (covRS) mutation. The results have provided a paradigm where natural selection exerted by the innate immune system has generated hypervirulent bacterial variants with increased risk of systemic dissemination.

Risk factors, Streptococcus pyogenes, Clinical report

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Side effects may include evolution

Article Abstract:

The study that provides an example of how certain antibiotics could prompt Streptococcus pneumoniae to take up DNA from the environment, which might enable the microbe to acquire genes for antibiotic resistance. Findings suggest that the presence of the antibiotic results in the formation of single-stranded DNA (either from direct DNA damage or from impaired replication) which templates the formation of RecA filaments, which facilitate recombinational repair.

United States, Recombinant DNA Products, Genetic aspects, Recombinant DNA, Streptococcus pneumoniae

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A new algorithm weighs in

Article Abstract:

A new algorithm called genetic regulatory modules (GRAM) that combines physical and functional information can be used for determining genetic regulatory networks. A mechanistic explanation of genetic regulatory networks is provided by the GRAM algorithm, which takes into consideration the mechanism of protein deoxyribonucleic acid (DNA) -binding events and the consequences of the mechanism, which consists of expression data.

Nucleic Acids, Genetic algorithms

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