Decreased histone deacetylase activity in chronic obstructive pulmonary disease

Article Abstract:

Chronic obstructive pulmonary disease (COPD), characterized by chronic airway inflammation is greater in patients with advanced disease. Histone deacetylase (HADC) activity and histone acetyltransferase (HAT) activity were determined in nuclear extracts of specimens of surgically resected lung tissue from nonsmokers without COPD, patients with COPD of varying severity, and patients with pneumonia or cystic fibrosis.

United Kingdom, Care and treatment, Histones

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The nature of small-airway obstruction in Chronic obstructive pulmonary disease (COPD) is a major health problem, which is caused due to excessive exposure to toxic gases and particles. It is concluded that COPD is associated with a thickening of the airway wall, which results in the accumulation of inflammatory exudates in the lumen.

Article Abstract:

Chronic obstructive pulmonary disease (COPD) is a major health problem, which is caused due to excessive exposure to toxic gases and particles. It is concluded that COPD is associated with a thickening of the airway wall, which results in the accumulation of inflammatory exudates in the lumen.

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Small airways in COPD

Article Abstract:

Chronic obstructive pulmonary disease is a major growing problem, which is caused by long-term exposure of noxious gases. The study highlights the importance of inflammation in small airways as a determinant of the progression and severity of disease.

All Other Basic Organic Chemical Manufacturing, Industrial organic chemicals, not elsewhere classified, Poison Gases, Gases, Asphyxiating and poisonous, Poisonous gases

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