Detection of semen in cervicovaginal secretions

Article Abstract:

Routine use of tests to detect the presence of semen in cervical and vaginal fluids may reduce the number of false-positive results caused by contamination with semen. A semen detection test known as the seminal fluid assay (SEMA) identified the presence of sperm up to 24 hours after unprotected intercourse. SEMA is an enzyme-linked immunosorbent assay (ELISA) method that uses the monoclonal antibody MHS-5 to detect a protein found in semen. Microscopic examination could only detect sperm within eight hours of unprotected intercourse. Such tests have been used to investigate cases of rape. Their routine use in medical studies may reduce the number of false-positive results caused by semen contamination following recent intercourse.

Analysis, Measurement, Semen, Body fluids

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Inhibition of replication of HIV-1 at both early and late stages of the viral life cycle by single-chain antibody against viral integrase

Article Abstract:

Inhibition of the viral enzyme integrase with an antibody may reduce the infectivity of HIV. Researchers created a recombinant gene encoding an antigen-binding antibody and applied it to CD4 white blood cells. Genetically transfected cells were resistant to HIV infection. Inhibition of the viral enzyme appears to interfere with the insertion of viral genetic material into host cell DNA. An antibody that acts within host cells, rather than outside of cells, may provide some resistance to HIV infection.

Japan, HIV (Viruses), HIV

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Quantitation of HIV-1-specific IgG, IgA, and IgM antibodies in human genital tract secretions

Article Abstract:

Immunoglobulin (Ig) G antibodies to HIV are present in most semen samples from men and cervicovaginal samples from women with HIV infection. IgA antibodies to HIV were detected in 71% of semen samples, but in only 8% of samples from women. IgG levels in genital tract secretion of women were significantly higher when HIV was contracted by heterosexual sex.

Statistical Data Included, Immunoglobulins

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