Determinants of survival without antiretroviral therapy after infancy in HIV-1-infected Zambian children in the CHAP trial

Article Abstract:

Children with HIV Antibiotic Prophylaxis (CHAP) are a randomized trial comparing cotrimoxazole prophylaxis with placebo in HIV-infected Zambian children and the prognostic value of baseline characteristics is investigated by using Cox models. Malnutrition and hospitalizations for respiratory/bacterial infections have predicted mortality independent of immunosuppression, which has indicated that they capture HIV- and non-HIV-related mortality, whereas oral candidiasis is a proxy for immunosuppression.

HIV patients

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South Africa's "rollout" of highly active antiretroviral therapy: A critical assessment

Article Abstract:

South Africa's rollout of highly active antiretroviral therapy (HAART), which is found to be poor in comparison with other countries and in relation to the governments own targets, is discussed. The findings reveal that South Africa could have achieved a much higher HAART coverage than it has, as all the resources were made available to the Health Minister to facilitate a HAART rollout by the national Treasury, a significant portion of which was not used for the purpose.

South Africa, Clinical report

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Antiretroviral therapy and congenital abnormalities in infants born to HIV-1-infected women in the United Kingdom and Ireland, 1990 to 2003

Article Abstract:

Analysis was undertaken to explore the relation between antiretroviral therapy (ART) in pregnancy and birth defects in infants born to HIV-infected women in the United Kingdom and Ireland between 1990 and 2003. The Findings are reassuring but continued monitoring is essential in view of the increasing number of women on therapy at conception and the likely continuing diversity of drug regimens.

Risk factors, Pregnant women, Birth defects

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