Dickkopf-1 is a master regulator of joint remodeling

Article Abstract:

Tumor necrosis factor-[alpha] (TNF-[alpha]) is identified as a key inducer of Dickkopf-1 (DKK-1), a regulatory molecule of the wingless (Wnt) pathway, in the mouse inflammatory arthritis model and in human rheumatoid arthritis. The results have indicated that the Wnt pathway is a key regulator of joint remodeling and the expression of DKK-1 in inflammatory and degenerative joint disease might inhibit bone formation without the joint, further biasing the imbalance toward bone resorption.

Europe, Health aspects, Causes of, Tumor necrosis factor, Joint diseases, Tumour necrosis factor

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Clinical implications of the Osteoprotegerin/RANKL/RANK system for bone and vascular diseases

Article Abstract:

The clinical implications of the decoy receptor osteoprotegerin/receptor activator of nuclear factor Kappa B ligand/receptor activator of nuclear factor Kappa (OPG/RANKL/RANK) system for bone and vascular diseases are summarized. The RANKL has been identified, as an essential cytokine for the formation and activation of osteoclast were the effects of RANKL are physiologically counterbalanced by the OPG.

Blood circulation disorders, Vascular diseases

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Soluble RANKL and risk of nontraumatic fracture

Article Abstract:

The receptor activator of nuclear factor kB ligand (RANKL) is essential for osteoclast and may represent a key link between bone formation and resorption. Studies show that a low level of RANKL is an independent predictor of nontraumatic fracture.

Influence, Ligand binding (Biochemistry), Fractures (Injuries), Fractures

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