Disruption of methylarginine metabolism impairs vascular homeostasis

Article Abstract:

The function of dimethylarginine dimethylaminohydrolase 1 (DDAH-1) is examined by deleting the Ddah 1 gene in mice and by using DDAH-specific inhibitors that bind to the active site of human DDAH-1. The results have shown that the loss of DDAH-1 activity leads to accumulation of ADMA (asymmetric dimethylarginine) and reduction in NO signaling.

United Kingdom, Industrial Gas Manufacturing, Industrial gases, Nitric Oxide, Health aspects, Physiological aspects, Homeostasis

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Secrets of a superbug

Article Abstract:

Two studies have examined the pathogenesis of the new antibiotic-resistant epidemic strains in Staphylococcus aureus. The studies have identified the clear role for specific virulence determinants in the pathogenesis of invasive community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) infections.

United States, Science & research, Research, Genetic aspects, Staphylococcus aureus, Control, Virulence (Microbiology), Staphylococcus aureus infections

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