Dissecting tumor maintenance requirements using bioluminescence imaging of cell proliferation in a mouse glioma model

Article Abstract:

A study is conducted to monitor the cell cycle in a genetically engineered, historically accurate model of glioma in vivo using bioluminescence imaging. It is suggested that the development of the Ef-luc mouse can be of great help in this process and will be a valuable tool in such in vivo explorations in the future.

Tumors, Cell proliferation, Tumours

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Imaging 26S proteasome activity and inhibition in living mice

Article Abstract:

The approach to 26S proteasome function in living animals that led to discovery of ubiquitin-luciferase for bioluminescence imagining is illustrated. The ubiquitin-proteasome acts as a central mediator to regulate proteolysis in cells.

Mice, Mice (Rodents), Proteolysis, Cell research, Cytological research

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Bioluminescent imaging of Cdk2 inhibition in vivo

Article Abstract:

Several biological pathways impinge on the action of ubiquitin ligases. Arrays of reporters probing orthogonal aspects of biological space can be used to monitor actions of drug-like molecules on biological systems.

Analysis, Usage, Imaging systems, Imaging

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