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Do tocolytic agents stop preterm labor? A critical and comprehensive review of efficacy and safety

Article Abstract:

Prostaglandin inhibitors may be the only tocolytic drugs that stop preterm labor. Tocolytic drugs are different substances that inhibit uterine contractions in premature labor. A survey was done of 328 studies published in the medical literature between 1933 and 1992 on the use of tocolytic drugs to stop preterm labor. Magnesium sulfate was not effective in stopping preterm labor, and beta-adrenergic receptor agonists are only effective for 24 to 48 hours. Both calcium channel blockers and oxytocin antagonists were effective in inhibiting uterine contractions, but their role in stopping preterm delivery was not defined. Prostaglandin inhibitors were effective in stopping preterm delivery and did not cause any serious side effects. Premature birth is a leading cause of death among newborn infants.

Author: Xenakis, Elly M.-J., Higby, Kenneth, Pauerstein, Carl J.
Publisher: Elsevier B.V.
Publication Name: American Journal of Obstetrics and Gynecology
Subject: Health
ISSN: 0002-9378
Year: 1993
Health aspects, Prevention, Premature labor, Tocolytic agents

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Accuracy and intraobserver variability of simulated cervical dilatation measurements

Article Abstract:

Estimations of cervical dilation by obstetrics health care providers may be accurate plus or minus one centimeter. Researchers asked 102 obstetricians, obstetrics residents, and labor and delivery nurses to estimate the amount of dilation in a simulated cervix by finger examination alone. Finger examinations were accurate plus or minus one centimeter of the actual dilation, and accuracy decreased as dilation increased. Doctors were no more accurate in their estimations than were labor and delivery nurses, regardless of years of practice. Estimates made by different providers could vary by more than 50%. This finding may need to be considered before determining the progress of cervical dilation in labor to be dysfunctional, especially when more than one provider is estimating dilation.

Author: Mayer, Allan R., Higby, Kenneth, Phelps, John Y., Smyth, Michael H., Ward, John A., Arredondo, Francisco
Publisher: Elsevier B.V.
Publication Name: American Journal of Obstetrics and Gynecology
Subject: Health
ISSN: 0002-9378
Year: 1995
Management, Labor (Obstetrics), Cervix uteri, Incompetent cervix

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Adnexal masses in pregnancy: a review of 130 cases undergoing surgical management

Article Abstract:

Surgeons report that the incidence of adnexal masses in pregnant women is 1 in 1,312 live births and 6% were malignant tumors. Adnexal masses are usually ovarian masses, which could be benign or cancerous. Surgery to remove the mass was safer when done before 23 weeks's gestation.

Author: Turner, Shannon, Higby, Kenneth, Whitecar, Paul
Publisher: Elsevier B.V.
Publication Name: American Journal of Obstetrics and Gynecology
Subject: Health
ISSN: 0002-9378
Year: 1999
Statistical Data Included, Surgery, Diseases, Pregnant women, Adnexa uteri

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