E2-EPF UCP targets pVHL for degradation and associates with tumor growth and metastasis

Article Abstract:

The von Hippel-Lindau tumor suppressor, pVHL, forms part of an E3 ubiquitin ligase complex that targets specific substrates for degradation hypoxia-inducible-1alpha, which is involved in tumor progression and angiogenesis. Study is presented to show that E2-EPF ubiquitin carrier protein (UCP) associates with and targets pVHL for ubiquitin-mediated proteolysis in cells, thereby stabilizing hypoxia-inducible-1alpha.

Physiological aspects, Transforming growth factors, Von Hippel-Lindau disease

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APC and colon cancer: two hits for one

Article Abstract:

The article discusses the effect of the dysfunction of the adenomatous polyposis coli (APC) tumor suppressor genes on chromosomal irregularities observed in precancerous cells. It is observed that APC mutations often lead to the colon cancer in individuals.

Polyposis, Familial, Familial polyposis, Colon cancer

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Bird flu almighty

Article Abstract:

Studies on the growth, virulence, transmission and aftereffects of infection of the H5N1 'bird flu' virus are presented.

Development and progression, Avian influenza

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