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Effectiveness of adjunctive antidepressant treatment for bipolar depression

Article Abstract:

Treatment of depression in patients with bipolar disorder with mood stabilizers and antidepressant medication was found to be just as beneficial as treatment with only mood stabilizing medicines. Further the use of adjunctive, standard antidepressant medication, as compared to the use of mood stabilizers, was not associated with increased efficacy or with increased treatment-emergent affective switch.

Author: Thase, Michael E., Bowden, Charles L., Hauser, Peter, Sachs, Gary S, Nierenberg, Andrew A, Calabrese, Joseph R, Marangell, Lauren B., Wisniewski, Stephen R, Gyulai, Laszlo, Friedman, Edward S, Fossey, Mark D, Ostacher, Michael J, Ketter, Terence A, Patel, Jayendra, Rapport, Daniel, Martinez, James M, Allen, Michael H., Miklowitz, David J, Otto, Michael W, Dennehy, Ellen B
Publisher: Massachusetts Medical Society
Publication Name: The New England Journal of Medicine
Subject: Health
ISSN: 0028-4793
Year: 2007
Bipolar disorder, Clinical report

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Medication augmentation after the failure of SSRIs for depression

Article Abstract:

The efficacy of adding a second medication to an initial, ineffective anti-depressant drug was tested with the augmentation of citalopram with either sustained-release bupropion or buspirone. It was found that augmentation with sustained-release bupropion does have certain advantages including greater reduction in the number and severity of symptoms and fewer side effects and adverse events.

Author: Thase, Michael E., Trivedi, Madhukar H., Rush, A. John, Biggs, Melanie M., Wisniewski, Stephen R., Lebowitz, Barry D., Ritz, Louise, Warden, Diane, Luther, James F., Shores-Wilson, Kathy, Maurizio, Fava, Quitkin, Frederick, Nierenberg, Andrew A.
Publisher: Massachusetts Medical Society
Publication Name: The New England Journal of Medicine
Subject: Health
ISSN: 0028-4793
Year: 2006
Depression, Mental, Depression (Mood disorder), Serotonin uptake inhibitors, Selective serotonin reuptake inhibitors, Bupropion, Buspirone hydrochloride, Buspirone, Citalopram

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Electroconvulsive therapy for depression

Article Abstract:

A case study of an 82-year-old widowed woman with a history of recurrent unipolar major depression is reported. The patient was recommended for the electroconvulsive therapy (ECT) due to lack of response to or intolerance of adequate trials of antidepressant medications and neuroleptic agents.

Author: Lisanby, Sarah D.
Publisher: Massachusetts Medical Society
Publication Name: The New England Journal of Medicine
Subject: Health
ISSN: 0028-4793
Year: 2007
Care and treatment, Usage, Case studies, Electroconvulsive therapy, Electroshock, Depression in old age, Geriatric depression

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Subjects list: Complications and side effects, Drug therapy, Dosage and administration, Antidepressants, United States
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