Effects of citalopram and interpersonal psychotherapy on depression in patients with coronary artery disease: The Canadian Cardiac Randomized Evaluation of Antidepressant and Psychotherapy Efficacy (CREATE) trial

Article Abstract:

A study is conducted to document the short-term efficacy of a selective serotonin reuptake inhibitor (citalopram) and interpersonal psychotherapy (IPT) in reducing depressive symptoms in patients with coronary artery disease (CAD) and major depression. Results show no evidence of added value of IPT over clinical management, indicating that citalopram or sertraline plus clinical management should be considered as a first-step treatment for patients with CAD and major depression.

United States, Drug therapy, Serotonin uptake inhibitors, Selective serotonin reuptake inhibitors, Clinical report, Interpersonal psychotherapy

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Depression -- a cardiac risk factor in search of a treatment

Article Abstract:

Treating heart attack patients for their depression may not necessarily improve their prognosis, according to a study published in 2003. This was surprising because other studies showed that heart attack patients with depression have lower survival rates compared to non-depressed patients. An overall improvement in the care of heart attack patients in general may have minimized the impact of treatment for depression.

Editorial

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Effects of treating depression and low perceived social support on clinical events after myocardial infarction: the Enhancing Recovery in Coronary Heart Disease patients (ENRICHD) randomized trial

Article Abstract:

Treating heart attack patients for their depression may be effective but it will not prolong their survival, according to a study of 2,481 patients. Some received usual care and others received cognitive behavior therapy and medication if necessary. This study was done because research has shown that heart attack patients who are depressed have a worse prognosis than other heart attack patients.

Evaluation, Cognitive therapy

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