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Efficacy and Safety of Adefovir Dipivoxil With Antiretroviral Therapy: A Randomized Controlled Trial

Article Abstract:

The drug adefovir dipivoxil appears to be effective in treating HIV infection, especially in patients whose HIV is resistant to other AIDS drugs. One benefit of this drug is that it only has to be taken once a day. Researchers randomly assigned 442 HIV-infected patients to take adefovir dipivoxil once a day or a placebo. Patients taking adefovir dipivoxil had a decrease in blood viral levels but those in the placebo group did not. CD4 counts did not change in either group. The drug caused some liver and kidney damage after long-term use, but the damage was reversed when the drug was discontinued.

Author: Beall, Gildon, Cooper, Richard, Basgoz, Nesli, Hardy, David, Miller, Michael, Wulfsohn, Michael, Lagakos, Stephen, Kahn, James, Murphy, Robert, Toole, John J., Cherng, Deborah, Cherrington, Julie, Ng, Edmund, Deeks, Steven, Winslow, Dean, Coakley, Dion
Publisher: American Medical Association
Publication Name: JAMA, The Journal of the American Medical Association
Subject: Health
ISSN: 0098-7484
Year: 1999

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Response to antiretroviral therapy after a single, peripartum dose of nevirapine

Article Abstract:

A prospective observational study was conducted to assess the virologic responses of women and infants to nevirapine-based antiretroviral treatment after previous exposure to a single dose of nevirapine or placebo in the setting of a short course of zidovudine. Results revealed that women who received a single dose of nevirapine to prevent perinatal transmission of HIV-1 had higher rates of virologic failure with subsequent nevirapine-based antiretroviral therapy than did women without previous exposure to nevirapine.

Author: Smeaton, Laura M., Lockman, Shahin, Shapiro, Roger L.
Publisher: Massachusetts Medical Society
Publication Name: The New England Journal of Medicine
Subject: Health
ISSN: 0028-4793
Year: 2007
United States, HIV infection in children, Pediatric HIV infections, Antiviral agents, Nevirapine, Antiretroviral agents

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Breastfeeding plus infant Zidovudine Prophylaxis for 6 months versus formula feeding plus infant Zidovudine for 1 month to reduce mother-to-child HIV

Article Abstract:

The efficacy and safety of 2 infant feeding strategies for the prevention of postnatal mother-to-child HIV transmission is compared. It is observed that the formula feeding infants had a higher risk of early mortality and breast feeding infants had a higher risk of HIV transmission in sub-Saharan Africa.

Author: McIntosh, Kenneth, Essex, Max, Kim, Soyeon, Gilbert, Peter B., Heymann, S. Jody, Lagakos, Stephen, Marlink, Richard, Smeaton, Laura M., Mazonde, Patson, Thior, Ibou, Lockman, Shahin, Shapiro, Roger L., Wester, Carolyn, Stevens, Lisa, Peter, Trevor, Widenfelt, Erik van, Moffat, Claire, Ndase, Patrick, Arimi, Peter, Kebaabetswe, Poloko, Makhema, Joseph, Novitsky, Vladimir, Tun-Hou, Lee
Publisher: American Medical Association
Publication Name: JAMA, The Journal of the American Medical Association
Subject: Health
ISSN: 0098-7484
Year: 2006
Africa, Prevention, Infants, Dosage and administration, Breast feeding, Zidovudine

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Subjects list: HIV infection, Drug therapy, HIV infections, Health aspects, Clinical report
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