Evaluation of Contraceptive Efficacy and Cycle Control of a Transdermal Contraceptive Patch vs an Oral Contraceptive: A Randomized Controlled Trial

Article Abstract:

A weekly contraceptive patch may be more effective for some women than an oral contraceptive, according to a study of 1,417 women. Compliance was higher in the women who used the patch, but they also had more adverse reactions.

Transdermal medication, Transdermal drug delivery systems, Dosage and administration, Contraceptives

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Placental passage of the oxytocin antagonist atosiban

Article Abstract:

Atosiban appears to cross the placenta in only minimal amounts and seems to have no adverse effects on fetal oxygenation or on maternal blood loss after delivery. Atosiban is a new drug that relaxes the uterus. Eight women having an elective cesarean section at term were given an intravenous infusion of atosiban over 208 to 443 minutes prior to delivery. The average concentration of drug in the maternal uterine vein at delivery was 332 nanograms per milliliter but the concentration in the fetal umbilical vein was only 42 nanograms per milliliter. Longer infusion times did not increase atosiban levels in the fetus. Fetal blood pH, which is a measure of oxygenation, was similar to a group of 60 women having elective cesareans who did not receive atosiban. Medication to control blood loss was used more often in the atosiban group and one woman hemorrhaged.

Physiological aspects, Drug therapy, Premature labor, Hormone antagonists, Tocolytic agents

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