Fibrinolytic components in fetal membranes and amniotic fluid

Article Abstract:

The balance of fibrinolytic activators and inhibitors in fetal membranes and amniotic fluid may play an important role in triggering the rupture of fetal membranes before birth. Fibrinolytic activators and inhibitors are substances involved in the regulation of different biological processes such as blood clot formation, ovulation and embryo implantation. A study measured the levels of fibrinolytic activators and inhibitors in amniotic fluid and blood and in fetal membranes. Increased levels of plasminogen activator inhibitor-1 were found in amniotic fluid and the chorion, the outermost extraembryonic membrane. A high concentration of plasminogen activator-2 was found in the decidua, the lining of the pregnant uterus. Increased levels of plasminogen activators and plasminogen were found in the amniotic epithelium. Plasminogen activator inhibitor-1, plasminogen activator inhibitor-2 and alpha 2-plasmin inhibitor were not found in the amniotic epithelium.

Fetal membranes

---

The effect of low amniotic pressure without oligohydramnios on fetal lung development in a rabbit model

Article Abstract:

Low amniotic pressure interferes with fetal lung development even in the absence of oligohydramnios, or very low levels of amniotic fluid. Researchers created pressure loss in the amniotic sac of 20 rabbits by allowing extra fluid movement through a protected pocket in the uterine wall. Cutting through the wall removed the natural support of the uterus and produced lower amniotic pressure. The hernia operation took place on day 23 of the pregnancy followed by cesarean sections at term, on day 31. After surgery, lung functions differed between ten surviving fetuses and 14 control animals. Amniotic pressure was much lower among the surgery group. Surgery animals had lower average ratios of lung weight to body weight compared to controls. In addition, the lung structures of operated rabbits were immature and fairly irregular in appearance. In contrast, control rabbits had fully developed lung airways.

Models, Causes of, Lungs, Lung, Embryology, Experimental, Embryological research, Anatomy, Respiratory insufficiency

---

The regulation of plasminogen activators and plasminogen activator inhibitor type 1 in endothelial cells by sex hormones

Article Abstract:

A type of estrogen known as 17-beta-estradiol may prevent blood clot formation in blood vessels by increasing the release of plasminogen activator. Researchers tested the effects of the sex hormones 17-beta-estradiol, progesterone, and testosterone on cells from the aortas of cows. The greatest increase in secretion of plasminogen activator occurred when aortic cells were exposed to low concentrations of the three hormones. 17-beta-estradiol caused the greatest stimulation of plasminogen activator. The effect on the aortic cells tapered off with higher concentrations of the hormones. Low levels of 17-beta-estradiol may cause blood clots to dissolve by increasing secretion and activity of plasminogen activator, but higher levels may cause blood clots to form.

Endothelium, Estradiol

Similar abstracts:

• Abstracts: Labouring in comfort. Assessing membrane rupture in labour. The conflict between lay and professional views of labour
• Abstracts: Training and employment programs in methadone treatment: client needs and desires. Health status of employed and unemployed methadone patients
• Abstracts: Pet-borne illness. Pets and you: Companions for health. Activity therapy
• Abstracts: Practice valuation: what does it mean? Sports in daily practice. Pricing and the perception of health care service quality
• Abstracts: Control of peripartal collagenolysis in the human chorion-decidua. Gamma-delta-T cells in human decidua

This website is not affiliated with document authors or copyright owners. This page is provided for informational purposes only. Unintentional errors are possible.