Functional engraftment of human ES cell-derived dopaminergic neuron enriched by coculture with telomerase-immortalized midbrain astrocytes

Article Abstract:

A new strategy for improving the efficiency of dopaminergic neurogenesis from human embryonic stem (HES)-cell cultures is discussed by using coculture with telomerase-immortalized human fetal mesencephalic astrocytes at the time of sonic hedgehog + fibroblast growth factor-mediated neuronal induction. Results show the utility of recreating the cellular environment of the developing human midbrain when driving dopaminergic neurogenesis from HES cells.

Human cell culture, Embryonic stem cells

---

Neuroprotective effects of creatine in a transgenic animal model of amyotrophic lateral aclerosis

Article Abstract:

Research has been conducted on creatine administration. Results indicate that oral administration of creatine improves motor performance, extends survival in transgenic mice and protects mice from motor neuron and nigra neuron loss and that creatine administration can become a therapeutics for amyotrophic lateral aclerosis treatment.

Health aspects, Physiological aspects, Therapeutics, Genetically modified animals, Oxidation, Physiological, Physiological oxidation, Creatine, Atrophy, Muscular, Muscular atrophy

---

Fetal and adult human oligodendrocyte progenitor cell isolates myelinate the congenitally dysmyelinated brain

Article Abstract:

Late-gestation and adult human forebrain, both contain large numbers of oligodendrocyte progenitor cells (OPCs). Adult OPCs generated oligodendrocytes more efficiently than fetal OPCs and ensheathed more host axons per donor cell than fetal cells.

Brain research, Axons, Fetal tissues

Similar abstracts:

• Abstracts: Estrogen-receptor status and outcomes of modern chemotherapy for patients with node-positive breast cancer. Adjuvant chemotherapy in older and younger women with lymph node-positive breast cancer
• Abstracts: Stem cells may offer incontinence cure. Primary care takes the lead in health. The next nursing century
• Abstracts: Outcomes of HIV-infected orphaned and non-orphaned children on antiretroviral therapy in western Kenya. The seroepidemiology of human T-lymphotropic viruses: Types I and II in Europe: A prospective study of pregnant women
• Abstracts: In vivo imaging of lymph node metastasis with telomerase-specific replication-selective adenovirus. Towering science: an ounce of creativity is worth a ton of impact
• Abstracts: Transcription meets metabolism in neurodegeneration. Increased apoptosis of Huntington disease lymphoblasts associated with repeat length-dependent mitochondrial depolarization

This website is not affiliated with document authors or copyright owners. This page is provided for informational purposes only. Unintentional errors are possible.