Growth hormone therapy in critically ill patients

Article Abstract:

Growth hormone probably should not be given to critically ill patients who don't have burns or trauma. A 1999 study found that critically ill patients who were given growth hormone had greater mortality rates than those who were not. Other studies have shown a benefit of growth hormone, but the patients had burns or severe trauma. One difference between the 1999 study and the others is that the patients developed the inflammation after they began taking growth hormone rather than before. Inflammation may protect patients from some of the effects of growth hormone.

Editorial

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Increased mortality associated with growth hormone treatment in critically ill adults

Article Abstract:

High doses of growth hormone may increase the risk of death in critically ill patients. In a study of over 500 intensive care patients, those who received growth hormone were twice as likely to die as those who did not. They also had longer hospital stays and were on a ventilator longer than patients who did not receive growth hormone.

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Efficacy and safety of eportin alfa in critically ill patients

Article Abstract:

Therapy with recombination human erythropoietin (eportin alfa) might reduce the need for red-cell transfusion is hypothesized. Results concluded that the use of eportin alfa does not reduce the incidence of red-cell transfusion among critically ill patients with trauma.

Health aspects, Drug therapy, Drug therapy, Combination, Combination drug therapy, Erythropoietin, Recombinant, Clinical report, Epoetin alfa

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