High-level chloramphenicol resistance in Neisseria meningitidis

Article Abstract:

Many strains of the bacterium Neisseria meningitidis appear to be resistant to chloramphenicol. This bacterium causes meningitis and is widespread in sub-Sahara Africa, the Middle East and Southeast Asia. Researchers tested 12 strains of the bacterium for chloramphenicol resistance. Eleven had been isolated from Vietnamese patients and one from a French patient. All were resistant to the antibiotic, and resistance was traced to a gene that all strains contained. This is a serious problem because intramuscular chloramphenicol is a standard treatment for meningitis caused by this organism.

Neisseria meningitidis, Chloramphenicol

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Vancomycin-resistant enterococcal infections

Article Abstract:

Hospitals must implement strict infection control procedures to reduce the risk of vancomycin-resistant enterococcal infections. Enterococci are bacteria that live in the gastrointestinal tract, and are usually spread by contact with feces. When these bacteria become resistant to antibiotics, they are especially difficult to treat. Widespread use of vancomycin in hospitals has caused enterococci to become resistant to the drug. Some are also resistant to derivatives of penicillin. Because the bacterium can spread to other hospital patients, it is critical to control any outbreaks.

Analysis, Enterococcus

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The development of vancomycin resistance in a patient with methicillin-resistant Staphylococcus aureus infection

Article Abstract:

The case of a 79-year-old man indicates that there are strains of the bacterium Staphylococcus (S.) aureus in the US that are resistant to vancomycin. He had end-stage kidney disease and was on dialysis. He was admitted to a hospital with fever and altered mental status and was found to be infected with methicillin-resistant S. aureus. Despite treatment with vancoymcin, he died. The bacterium was isolated from some specimens before he died, and testing revealed that it was resistant to vancomycin.

Staphylococcus aureus, Vancomycin

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