Human tissue-engineered blood vessels for adult arterial revascularization

Article Abstract:

Cardiovascular tissue engineering introduced the prospect of a completely biological, living and autologous blood vessel produced in vitro to fill the crucial need for functional small-diameter conduits. Using adult human fibroblasts extracted from skin biopsies harvested from individuals with advanced cardiovascular disease, tissue-engineered blood vessels (TEBVs) that serve as arterial bypass grafts in long-term animal models is constructed.

Cardiovascular diseases, Fibroblasts, Tissue engineering, Vascular grafts

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Engineered antibodies

Article Abstract:

In the biopharamaceuticals development, engineered antibodies form a significant part and replace the antibodies developed using hybridoma technology. The engineered antibodies facilitate designing antibody-based reagents with specificity. They can be reduced in size into antibody fragments, developed into multiple specificity molecules, and fused with radionuclides, toxins, enzymes, liposomes and viruses.

Australia, Innovations, Design and construction, Protein engineering, Viral antibodies, Antibodies, Biopharmaceutics, Biopharmaceuticals

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Viral receptors and vector purification: new approaches for generating clinical-grade reagents

Article Abstract:

Vector purification and viral receptors are discussed with consideration of new approaches for generating clinical-grade reagents. Topics include immuno-affinity chromatography, using a monoclonal antibody, and heparin affinity chromatography. Purification of recombinant adeno-associated virus (AAV) vectors is discussed with consideration of the benefits of the new methods.

United States, Instrument industry, Instrument industry (Equipment), Usage, Pharmaceutical industry, Product information, Chemical industry, Cytochemistry, Ligands, Ligands (Chemistry), Chromatography, Chemical tests and reagents, Reagents

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