Hypothalamic sensing of circulating fatty acids is required for glucose homeostasis

Article Abstract:

Physiological increments in plasma fatty acids could be sensed within the hypothalamus and could be used to balance their direct stimulatory action on hepatic gluconeogenesis. Experiments indicate that a physiological elevation in circulating lipids could be sensed within the hypothalamus and that a defect in hypothalamic lipid sensing disrupts glucose homeostasis.

All Other Miscellaneous Chemical Product and Preparation Manufacturing, Chemical preparations, not elsewhere classified, Fatty Acids & Derivatives, Fatty acids, Hypothalamus, Homeostasis

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Inhibition of hypothalamic carnitine palmitoyltransferase-1 decreases food intake and glucose production

Article Abstract:

The enzyme carnitine palmitoytransferase-1 (CPT 1) regulates long-chain fatty acid entry into mitochondria, where the LCFAs undergo beta-oxidation. To substantially diminish food intake and endogenous glucose production, the genetic or biochemical inhibition of hypothalamic CPT1 activity was sufficient.

Enzymes, Other Basic Organic Chemical Manufacturing

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Brain glucose metabolism controls the hepatic secretion of triglyceride-rich lipoproteins

Article Abstract:

A selective increase in brain glucose has lowered circulating triglycerides (TG) through the inhibition of TG-very low-density lipoprotein (VLDL) secretion by the liver. The results have indicated that a defect in brain glucose sensing might play a key role in the etiology of the metabolic syndrome.

Health aspects, Physiological aspects, Triglycerides, Neurosecretion

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