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Recombinant modified vaccinia virus Ankara expressing antigen 85A boosts BCG-primed and naturally acquired antimycobacterial immunity in humans

Article Abstract:

The results of a series of phase I studies in human volunteers evaluating the safety and immunogenicity of modified vaccinia virus Ankara (MVA) expressing antigen 85A (MVA85A) first in BCG-naive healthy volunteers and subsequently in volunteers who are vaccinated with BCG 0.5-38 years previously is reported. The findings show that immunization with MVA85A boosts the preexisting antimycobacterial immunity induced by BCG in these volunteers.

Author: Hill, Adrian V.S., Gilbert, Sarah C., McShane, Helen, Pathan, Ansar A., Sander, Clare R., Keating, Sheila M., Huygen, Kris, Fletcher, Helen A.
Publisher: Nature America, Inc.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2004
HEALTH SERVICES, All Other Miscellaneous Ambulatory Health Care Services, Vaccination & Immunization, Analysis, Vaccination, Mycobacterium tuberculosis, Immune response

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Enhanced T-cell immunogenicity of plasmid DNA vaccines boosted by recombinant modified vaccinia virus Ankara in humans

Article Abstract:

A heterologous prime-boost vaccination regime of DNA either intramuscularly or epidermally, followed by intradermal recombinant modified vaccinia virus Ankara (MVA), induces antigen-specific T-cell responses in humans. A basis for preventive and therapeutic vaccination in humans may be provided by such heterologous prime-boost immunization approaches.

Author: Brown, Karen, Sinden, Robert E., McConkey, Samuel J., Reece, William H H., Moorthy, Vasee S., Webster, Daniel, Dunachie, Susanna, Butcher, Geoff, Vuola, Jenni M., Blanchard, Tom J., Gothard, Philip, Watkins, Kate, Hanman, Carolyn M., Everaere, Simone, Kester, Kent E., Cummings, James, Williams, Jackie, Heppner, D Gray, Pathan, Ansar, Flanagan, Katie, Roberts, Mark T. M., Arunlanathamn, Nirmala, Roy, Michael, Smith, Geoffrey L., Schneider, Joerg, Peto, Tim, Gilbert, Sarah C., Hill, Adrian V. S.
Publisher: Nature America, Inc.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2003
Immunization, DNA vaccines

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A CD4+ T-cell immune response to a conserved epitope in the circumsporozoite protein correlates with protection from natural Plasmodium falciparum infection and disease

Article Abstract:

Interferon-gamma-secreting CD4(super +) Tcells is detected for a conserved sequence from the circumsporozite protein that bids to many human leukocyte antigen (HLA)-DR types. Findings are presented that proves a protective role of CD4(super +) Tcells in humans and a precise target for design of improved vaccines against Plasmodium falciparum.

Author: Greenwood, Brian M., Everaere, Simone, Reece, William H.H., Milligan, Paul, Watkins, Katherine R., Alloueche, Ali, McAdam, Keith P.W.J., Pinder, Margaret, Gothard, Philip K., Bojang, Kalifa, Doherty, Tom, Plebanski, Magdalena, Akinwunmi, Peter, Voss, Gerald, Tornieporth, Nadia, Kester, Kent E., Cohen, Joe; Hill, Adrian V.S.
Publisher: Nature America, Inc.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2004
HLA histocompatibility antigens, HLA antigens, Malaria, Histocompatibility antigens

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Subjects list: Research, United States, T cells
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