Immunoglobulin A anti-beta(sub 2)-glycoprotein antibodies in women who experience unexplained recurrent spontaneous abortion and unexplained fetal death

Article Abstract:

Pregnant women with antibodies against beta(sub 2)-glycoprotein have a higher than normal risk of miscarriage and stillbirth. These antibodies are a specific type of antiphospholipid antibodies, and may be a marker for an underlying autoimmune disorder.

Risk factors, Still-birth, Stillbirth

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Induction of high levels of anticardiolipin antibodies in mice by immunization with beta2-glycoprotein I does not cause fetal death

Article Abstract:

Inducing production of anticardiolipin antibodies in pregnant mice may not result in fetal death. Researchers immunized pregnant mice with beta-2-glycoprotein I to induce the antiphospholipid syndrome, which is associated with recurrent miscarriage and fetal death in humans. Pregnancy rates were similar among immunized and control mice. The fetal death rate was also similar among immunized and control mice even though immunized mice had high levels of anticardiolipin antibodies. It is possible that certain anticardiolipin antibodies may not cause adverse effects. Human anticardiolipin antibodies are known to adversely affect pregnancy in mice. Discovering the differences between neutral and harmful anticardiolipin antibodies may help in developing treatments for antiphospholipid syndrome.

Models, Physiological aspects, Antiphospholipid syndrome, Anticardiolipin antibodies, Fetal death

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Variable effects on murine pregnancy of immunoglobulin G fractions from women with antiphospholipid antibodies

Article Abstract:

Fetal loss patterns do not seem to be consistent in mice immunized with immunoglobulin G from women with antiphospholipid antibodies. Immunoglobulin G was isolated from 20 women with antiphospholipid antibodies and injected into two strains of pregnant mice according to one of two immunization schedules. Twenty-two percent of the fetal mice died. Many fetuses died when mice were injected with immunoglobulin G samples from eight women. Otherwise there was little correlation between patient source and fetal death. More mice did not die as immunoglobulin G levels increased. Patterns were similar in both strains of mice.

Causes of, Immunoglobulin G

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