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Increase and plateau orf CD4 T-cell counts in the 3-1/2 years after initiation of potent antiretroviral therapy

Article Abstract:

Highly active antiretroviral therapy (HAART) will decrease viral levels and increase CD4 T cell count, but only up to a certain point. About three years after treatment starts, both viral levels and CD4 T cell counts reach a plateau and don't change any further.

Author: Detels, Roger, Munoz, Alvaro, Margolick, Joseph B., Phair, John P., Tarwater, Patrick M., Jin, Jianhua, Rinaldo, Charles, Giorgi, Janis
Publisher: Lippincott Williams & Wilkins, WK Health
Publication Name: Journal of Acquired Immune Deficiency Syndromes (1999)
Subject: Health
ISSN: 1525-4135
Year: 2001
Physiological aspects, Anti-HIV agents

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Effectiveness of Potent Antiretroviral Therapy on Time to AIDS and Death in Men With Known HIV Infection Duration

Article Abstract:

Potent antiretroviral drugs have significantly delayed the progression of HIV infection to AIDS, and improved the survival of HIV patients. Researchers compared 536 patients who contracted HIV from 1984 to 1997. Early HIV treatment was with a single drug, such as zidovudine, while patients infected later used combined drug therapy and, recently, potent antiretroviral drugs. Patients treated with antiretroviral drugs progressed to AIDS later than those given monotherapy or combined drug therapy, and patients on antiretroviral agents had slower declines in CD4 white blood cell counts.

Author: Detels, Roger, Munoz, Alvaro, Margolick, Joseph B., Phair, John P., Giorgi, Janis, Kingsley, Lawrence A., Schrager, Lewis K., McFarlane, Glen
Publisher: American Medical Association
Publication Name: JAMA, The Journal of the American Medical Association
Subject: Health
ISSN: 0098-7484
Year: 1998
Evaluation, Development and progression, Drug therapy, Antiviral agents, AIDS (Disease), Zidovudine

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Impact of potent antiretroviral therapy on the incidence of Kaposi's sarcoma and non-Hodgkin's lymphomas among HIV-1-infected individuals

Article Abstract:

The authors explore the relationship between the use of antiretroviral therapy for HIV-infected patients and the incidence of either Kaposi's sarcoma (KS) or non-Hodgkin's lymphoma (NHL). They found that the incidence of KS had declined significantly but that cases of NHL continued to rise.

Author: Chmiel, Joan S., Detels, Roger, Munoz, Alvaro, Margolick, Joseph B., Melnick, Sandra, Jacobson, Lisa P., Kingsley, Lawrence A., Yamashita, Traci E.
Publisher: Lippincott Williams & Wilkins, WK Health
Publication Name: Journal of Acquired Immune Deficiency Syndromes (1999)
Subject: Health
ISSN: 1525-4135
Year: 1999
Health aspects, Statistical Data Included, Complications and side effects, Statistics, HIV patients, Non-Hodgkin's lymphomas, Kaposi's sarcoma, Antirheumatic agents

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Subjects list: HIV infection, HIV infections
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