Inhibition of respiratory viruses by nasally administered siRNA

Article Abstract:

A demonstration that individual as well as joint infection by respiratory syncytial virus (RSV) and parainfluenza (PIV) could be specifically prevented and inhibited by short interfering RNAs (siRNAs), instilled intranasally in the mouse, with or without transfection reagents is presented using an RNA interference (RNAi) approach. The results reveal that, if properly designed, low dosages of inhaled siRNA might offer a fast, potent and easily adminstrable antiviral regimen against respiratory viral disease in humans.

Respiratory syncytial virus, Parainfluenza viruses

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Intranasal delivery of the cytoplasmic domain of CTLA-4 using a novel protein transduction domain prevents allergic inflammation

Article Abstract:

A study aims to utilize the cytoplasmic domain of CTLA-4 to suppress allergic inflammation by fusing it to a novel protein-transduction domain in the human transcriptional factor Hph-1, and verified transduction efficiency in vitro and in vivo after ocular, intranasal and intradermal administration. Results indicate that a fusion protein Hph-1-ctCTLA-4 constitutes an effective immunosuppressive protein drug for potential use in the treatment of allergic asthma, through nasal administration.

Usage, Asthma, Inflammation, Messenger RNA, Cytoplasm, Intranasal medication, Nasal sprays

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Inhibition of respiratory syncytial virus infection with intranasal siRNA nanoparticles targeting the viral NS1 gene

Article Abstract:

A plasmid-borne small interfering RNA targeting the NS1 gene (siNS1) was used to examine the role of NS1 on modulating respiratory syncytial virus (RSV) infection. Mice treated intranasally with siNS1 nanoparticles before or after infection with RSV showed substantial decreased virus titers in the lung and decreased inflammation and airway reactivity compared to controls.

Genetic aspects, Respiratory syncytial virus infection

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