Interaction of anti-HIV protease inhibitors with the multidrug transporter P-glycoprotein (P-gp) in human cultured cells

Article Abstract:

The protease inhibitors which have proven successful in reducing HIV replication may be limited in oral bioavailability by the same protein which transports the drug in the body. The protease inhibitors such as saquinavir, ritonavir, indinavir, and nelfinavir are all limited in their bioavailability, i.e., the amount of active ingredient which is actually use in the body as intended. The drug-transporting protein, P-glycoprotein (P-gp) is prevalent in the mucous of the intestine, and it seems to use the drugs as substrates which it affects and converts, taking most of it away from its intended function.

Evaluation, Ritonavir, Indinavir, Protease inhibitors, Saquinavir

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Obstetric and newborn outcomes in a cohort of HIV-infected pregnant women: a report of the Women and Infants Transmission Study

Article Abstract:

HIV-infected pregnant women are at higher risk for low-birth-weight infants, preterm birth, and other pregnancy complications. Researchers studied 634 HIV-positive pregnant women and their infants. One-fifth delivered prematurely, 19% delivered low-birth-weight babies, and 24% delivered babies small for their gestation age. Low CD4 white blood cell levels and a history of complicated pregnancy were particularly associated with these pregnancy outcomes. Socioeconomic and other factors, independent of HIV infection, also contribute to adverse outcomes of pregnancy.

Complications and side effects, Risk factors, HIV infections, Birth weight, Low, Low birth weight, Pregnancy, Premature birth, Pregnancy, Complications of, Pregnancy complications, HIV infection in pregnancy

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HIV and SIV envelope glycoproteins induce phospholipase A2 activation in human and macaque lymphocytes

Article Abstract:

Virus envelope glycoproteins from HIV and the simian immunodeficiency virus (SIV) activate the phospholipase A2 enzyme in human and macaque lymphocytic white blood cells. Specific mechanisms of viral fusion to lymphocyte membranes, necessary for cell infection, are discussed.

France, Statistical Data Included, Infection, HIV (Viruses), HIV, Lymphocytes, Phospholipases, Simian immunodeficiency virus

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