Successful islet transplantation for patients with diabetes -- fact or fantasy?

Article Abstract:

Pancreatic islet cell transplantation may be an option for many diabetics. In a study published in 2000, seven patients who received an islet cell transplant were able to stop using insulin for up to one year. At the annual American Diabetes Association meeting in June, 2000, researchers discussed patients who had gone for up to 13 years with a functioning pancreatic islet transplant. The main problem is how to supply enough pancreases for the number of diabetics who need treatment. A normal pancreas has about 1 million islet cells, but perhaps only 300,000 will be needed for each patient.

Editorial

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International trial of the Edmonton protocol for islet transplantation

Article Abstract:

Trials to explore the feasibility and reproducibility of islet transplantation by using Edmonton protocol so as to improve glycemic control in type 1 diabetes mellitus persons who are disabled by refractory hypoglycemia is conducted. This procedure successfully restores long-term endogenous insulin production and glycolic stability in cases of type 1 diabetes mellitus and unstable control but insulin independence is usually not sustainable and persistent islet function even without insulin independence provides protection from severe hypoglycemia and improved levels of glycated hemoglobin.

New England States, Health aspects, Islands of Langerhans, Islets of Langerhans

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Medical progress: islet transplantation as a treatment for diabetes - a work in progress

Article Abstract:

Pancreatic islet-cell transplantation as an evolving procedure is discussed. The potential of pancreas transplantation to provide type 1 diabetic patients with the possibility of an insulin-injection-free existence is described.

United States, Usage, Diagnosis

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