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Lack of macrophage fatty-acid-binding protein aP2 protects mice deficient in apolipoprotein E against atherosclerosis

Article Abstract:

Research has been conducted on the adipocyte fatty-acid-binding protein aP2 which plays important role in the insulin resistance and lipid metabolism. Results indicate that aP2 can be expressed in the macrophages and its effect on the biological responses of these macrophages has been investigated.

Author: Makowski, Liza, Boord, Jeffrey B., Maeda, Kazuhisa, Babaev, Vladimir R., Uysal, K. Teoman, Morgan, Maureen A., Parker, Rex A., Suttles, Jill, Fazio, Sergio, Hotamisligil, Gokhan S., Linton, MacRae F.
Publisher: Nature America, Inc.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2001
Statistical Data Included, Analysis, Causes of, Physiological aspects, Medical research, Carrier proteins, Transport proteins, Apolipoproteins, Macrophages, Lipid metabolism, Fatty acids, Atherosclerosis, Insulin resistance

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Cholesterol, racial variation and targeted medicines

Article Abstract:

Two nonsense, loss-of-function proprotein convertase subtilisin/kexin type 9 (PCSK9) mutations were identified, occurring in 2% of African Americans and less than 0.1% of European Americans and Hispanics. These mutations account for high or low blood LDL cholesterol.

Author: Topol, Eric J.
Publisher: Nature America, Inc.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2005
Science & research, Research, Gene mutations, Gene mutation, African Americans

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Subjects list: United States, Genetic aspects
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