Medical treatment of peptic ulcer disease: practice guidelines
Article Abstract:
The American College of Gastroenterology has published guidelines for the treatment of peptic ulcer. The treatment of peptic ulcer has been revolutionized with the discovery that a bacterium called Helicobacter (H.) pylori is associated with many cases of peptic ulcer. The use of non-steroidal anti-inflammatory drugs (NSAIDs) is another important cause of peptic ulcer. H. pylori infection can be diagnosed using the C14-urea breath test or by endoscopic biopsy. It can be treated with bismuth, metronidazole and tetracycline combined with a proton pump inhibitor. Once the bacterial infection is eradicated, the ulcer can be healed with histamine H2-receptor blockers such as cimetidine, proton pump inhibitors such as omeprazole, antacids and sucralfate. Patients with ulcers caused by NSAIDs should stop taking the drug if possible and be treated for H. pylori infection, which is present in half of these patients. Misoprostol can be used to prevent ulcers in people taking NSAIDs.
Publication Name: JAMA, The Journal of the American Medical Association
Subject: Health
ISSN: 0098-7484
Year: 1996
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Process of Care and Outcomes for Elderly Patients Hospitalized With Peptic Ulcer Disease Results From a Quality Improvement Project
Article Abstract:
More elderly patients with a peptic ulcer are being tested and treated for Helicobacter pylori but are not being cautioned about using non-steroidal anti-inflammatory drugs (NSAIDS). Both NSAIDS and Helicobacter pylori infection are risk factors for peptic ulcers.
Publication Name: JAMA, The Journal of the American Medical Association
Subject: Health
ISSN: 0098-7484
Year: 2001
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Improving Care for Elderly Patients With Peptic Ulcer Disease: Should the Focus Be on Drugs or Bugs?
Article Abstract:
Doctors should spend more time counseling elderly patients with peptic ulcer to avoid using non-steroidal anti-inflammatory drugs (NSAIDs). Testing them for Helicobacter pylori may also be effective, since this infection has been linked to peptic ulcer.
Publication Name: JAMA, The Journal of the American Medical Association
Subject: Health
ISSN: 0098-7484
Year: 2001
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