Living related-donor liver transplantation from adult to adult for primary biliary cirrhosis

Article Abstract:

Adult-to-adult living related-donor (LRD) liver transplantation may be successful in patients with terminal primary biliary cirrhosis. Primary biliary cirrhosis is a chronic inflammation of the liver. A 53-year-old woman suffered from primary biliary cirrhosis for 10 years and was treated with various therapies. She developed kidney failure, an increasing accumulation of fluid in the abdomen, and neuropsychiatric symptoms caused by liver damage. Surgeons performed an LRD liver transplantation using the left lobe of her 25-year-old son's liver. This portion of the son's liver accounted for 42% of the ideal liver mass needed by the woman. Two weeks after the transplant, the woman's liver function improved significantly and her neuropsychiatric symptoms resolved. Within six months, the patient's and donor's livers had regenerated and both mother and son made full recoveries.

Surgery, Biliary cirrhosis

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Peripheral nerves regenerated in familial amyloid polyneuropathy after live transplantation

Article Abstract:

Patients with hereditary amyloid polyneuropathy may benefit from a liver transplant. This is a nerve disorder caused by abnormal deposits of amyhloid protein. Nerve regeneration in the legs was evaluated before and three years after a liver transplant in a 34-year-old woman with hereditary amyloid polyneuropathy. There were 1,326 myelinated nerve fibers per square millimeter in a nerve serving the left calf before transplantation. This ratio increased to 4,740 myelinated nerves per square millimeter in a nerve serving the right calf after transplantation. However, evidence of amyloid deposits in these areas did not disappear after transplantation.

Amyloidosis, Nervous system, Nerve regeneration, Peripheral nerve diseases, Peripheral nervous system diseases

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Partial-Liver Transplantation To Treat Familial Amyloid Polyneuropathy: Follow-up of 11 Patients

Article Abstract:

A liver transplant may only be beneficial in patients with familial amyloid polyneuropathy (FAP) if they have a mild form of the disease and have not had the disease very long. FAP is a nerve disorder that is sometimes treated with a liver transplant. Of 11 patients with FAP who received a liver transplant, all 7 who had the disease for fewer than four years benefited from the treatment. They also had disease only in their legs. Patients who had the disease for 6 or more years or had disease in their arms and legs did not benefit from the transplant.

Familial diseases, Nervous system diseases

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