Loss of the tumor suppressor Vhlh leads to upregulation of Cxcr4 and rapidly progressive glomerulonephritis in mice

Article Abstract:

Investigations were carried out to show that deletion of the Von Hippel-Lindau gene (Vhlh) from intrinsic glomerular cells leads to stabilization of hypoxia-inducible factor subunits (HIFs) and the de novo expression of Cxcr4 was identified using gene profiling expression. The course of rapidly progressive glomerulonephritis was significantly improved in mice treated with a blocking antibody to Cxcr4, whereas overexpression of Cxcr4 alone in podocytes of transgenic mice caused glomerular disease.

Development and progression, Genetic aspects, Glomerulonephritis

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AML-1 steps up to the platelets

Article Abstract:

Conditional removal of the putative tumor suppressor gene Acute Myeloid Leukamia-1 (AML-1) encoded by the runt-related X1gene, (RUNX1) from the bone marrow of mice mimics a human familial platelet disorder. Details of the AML-1 and RUNX1 are discussed in detail.

Acute myelocytic leukemia, Blood platelet disorders, Platelet function disorders

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Fragile fugue: p53 in aging, cancer and IGF signaling

Article Abstract:

Aging is driven partly by an evolutionarily conserved hormone signaling pathway. A new study shows that the p53 tumor suppressor, which balances the need for cell proliferation against that for tumor suppression exquisitely, controls this pathway.

Aging, Aging (Biology)

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