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Maintenance therapy with certolizumab pegol for Crohn's disease

Article Abstract:

A randomized trial involving maintenance and withdrawal therapy with certolizumab pegol in patients with moderate-to-severe Crohn's disease is presented. Results show that patients who had a response to induction therapy with 400 mg of certolizumab pegol are more likely to have a maintained response and a remission at 26 weeks with continued treatment than with a switch to placebo.

Author: Hanauer, Stephen B., Thomsen, Ole Ostergaard, Sandborn, William J., Schreiber, Stefan, Bloomfield, Ralph, Khaliq-Kareemi, Mani, Lawrence, Ian C., McColm, Juliet
Publisher: Massachusetts Medical Society
Publication Name: The New England Journal of Medicine
Subject: Health
ISSN: 0028-4793
Year: 2007
Certolizumab pegol (Medication)

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Certolizumab pegol for the treatment of Crohn's disease

Article Abstract:

A study evaluates the efficacy of certolizumab pegol in adults with moderate-to-severe Crohn's disease. Findings suggest that induction and maintenance therapy with certolizumab pegol is associated with a modest improvement in response rates, as compared with placebo, but there is no significant improvement in remission rates.

Author: Feagan, Brian G., Mason, David, Rutgeerts, Paul, Sandborn, William J., Schreiber, Stefan, Stoinov, Simeon, Honiball, Pieter J., Bloomfield, Ralph
Publisher: Massachusetts Medical Society
Publication Name: The New England Journal of Medicine
Subject: Health
ISSN: 0028-4793
Year: 2007
HEALTH SERVICES, All Other Miscellaneous Ambulatory Health Care Services, Disease Testing Programs, Health aspects, Drugs, Drug evaluation, Certolizumab pegol (Medication)

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Natalizumab induction and maintenance therapy for Crohn's disease

Article Abstract:

Two controlled experiments are carried out to examine natalizumab as induction and maintenance treatments in patients suffering from active Crohn's disease. Findings indicate that for Crohn's disease, induction therapy with natalizumab produced small insignificant improvements in response and remission rates.

Author: Feagan, Brian G., Hanauer, Stephen B., Rutgeerts, Paul, Sandborn, William J., Schreiber, Stefan, Colombel, Jean Frederic, Enns, Roberts, Lawrance, Ian C., Panaccione, Remo, Sanders, Martin, Targan, Stephen, van Deventer, Sander, Goldblum, Ronald, Despain, Darrin, Hogge, Gary S.
Publisher: Massachusetts Medical Society
Publication Name: The New England Journal of Medicine
Subject: Health
ISSN: 0028-4793
Year: 2005
United Kingdom, Science & research, Research, Natalizumab

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Subjects list: Drug therapy, Dosage and administration, Crohn's disease, Clinical report
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