Matrix metalloproteinase activity in equine synovial fluid: influence of age, osteoarthritis, and osteochondrosis

Article Abstract:

Matrix metalloproteinase (MMP) activity appears to be greater in the synovial fluid of joints in young horses and horses with osteoarthritis (OA), compared to adult horses. MMPs are enzymes associated with cartilage growth and remodeling in joints. Researchers compared MMP levels in joint fluid samples from juvenile and adult horses and horses with OA or osteochondrosis. In healthy horses, MMP activity declined with age, indicating declining cartilage growth with age. In horses with OA, MMP activity was elevated, consistent with the cartilage destruction in this inflammatory condition. Osteochondrosis was not associated with increased MMP activity.

Netherlands, Osteochondrosis, Osteochondritis

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Influence of development and joint pathology on stromelysin enzyme activity in equine synovial fluid

Article Abstract:

The enzyme stromelysin is more active in joints affected by osteoarthritis, indicating that this increased activity may cause osteoarthritis. Stromelysin belongs to a class of enzymes called matrix metalloproteinases, which participate in the remodeling of connective tissue.

Causes of

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Urokinase-mediated fibrinolysis in the synovial fluid of rheumatoid arthritis patients may be affected by the inactivation of single chain urokinase type plasminogen activator by thrombin

Article Abstract:

The hormone thrombin may prevent the breakdown of blood clots in the joints of patients with rheumatoid arthritis. It does this by inhibiting another hormone called urokinase that breaks down blood clots.

Research, Blood clotting disorders, Blood coagulation disorders, Rheumatoid arthritis, Thrombin

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