Mechanical stress eliminates the effects of plasma from patients with preeclampsia on endothelial cells

Article Abstract:

The discrepancies between in vitro and in vivo studies on the production of various compounds by endothelial cells in women with preeclampsia could be explained by the stretching and deformation of blood cells that occurs in the body. Preeclampsia is a serious complication of pregnancy involving high blood pressure and protein in the urine. Researchers subjected cultured endothelial cells exposed to blood obtained from 12 preeclamptic patients and 12 pregnant women without preeclampsia to mechanical forces and measured the production of prostacyclin, endothelin and nitric oxide. Laminar shear stress substantially increased the production of prostacyclin and nitric oxide but not endothelin. Cyclic stretch raised endothelin levels but not prostacyclin or nitric oxide levels. Some researchers believe a chemical factor in the blood of some pregnant women can activate endothelial cells, causing preeclampsia.

Physiological aspects, Deformations (Mechanics), Deformation, Shear (Mechanics), Vascular endothelium

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The Trp64Arg polymorphism of the beta3-adrenergic receptor is not increased in women with preeclampsia

Article Abstract:

Preeclamsia is associated with the changes in the metabolic syndrome such as insulin resistance, hyperlipidemia, reduced high-density lipoprotein (HDL) cholesterol and increased uric acid. The Trp64Srg polymorphism of the beta3-receptor does not predispose to preeclampsia and it is not associated with obesity and carbohydrate intolerance in a population of young pregnant women.

Metabolic syndrome X

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Angiotensin-converting enzyme gene polymorphism in preeclampsia and normal pregnancy

Article Abstract:

The aim of the present study was to evaluate the angiotensin-converting enzyme gene polymorphism in women with and without preeclampsia. The results showed no association between angiotensin-converting enzyme polymorphism and the development of preeclampsia.

Angiotensin converting enzyme

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