Mitochondrial abnormalities in HIV-infected lipoatrophic patients treated with antiretroviral agents

Article Abstract:

The relation between clinical lipoatrophy (LA) and mitochondrial abnormalities occurring in the muscle of HIV-infected patients on highly active antiretroviral therapy (HAART) is investigated. The investigation confirmed that LA in long-term nucleoside reverse transcriptase inhibitors treated patients was associated with muscular mitochondrial dysfunction as shown by rapid lactic academia increase and mitochondrial histoenzymatic abnormalities.

Nucleic Acid Derivatives, Diagnosis, Nucleosides, Highly active antiretroviral therapy, Mitochondrial diseases

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Efficacy and tolerability of a nucleoside reserve transcriptase inhibitor-sparing combination of lopinavir/ritonavir and efavirenz in HIV-1-infected patients

Article Abstract:

Recommended antiretroviral regimens include a nucleoside reverse transcriptase inhibitor (NRTI) component and this class of antiretrovirals has problems such as class cross-resistance and mitochondrial toxicity. The lopinavir/ritonavir-efavirenz combination is associated with a high rate of virologic response and should be compared with more classic NRTI-containing regimens in randomized and controlled clinical trials.

Medical examination, HIV patients, Reverse transcriptase inhibitors

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Regulatory dysfunction of the interleukin-7 receptor in CD4 and CD8 lymphocytes from HIV-infected patients-Effects of antiretroviral therapy

Article Abstract:

Studies were conducted to evaluate the expression of the IL-7R alpha chain and to determine the responses of CD4 and CD8 T lymphocytes to IL-7 in three groups of chronically HIV-infected patients. Results reveal that the effects of HAART were less pronounced in patients with undetectable VL but low CD4 counts.

Biological products exc. diagnostic, Interleukin, HIV infection, HIV infections, Interleukins, CD4 lymphocytes

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